有無規律運動健康中年人體內C－反應蛋白及代謝症候群危險因子之比較

Comparison the Levels of C-Reactive Protein and Metabolic Syndrome Risk Factors Between Regular Exercise and Sedentary of Healthy Middle-Aged Adults

陳啟中(Chi-Chung Chen) ； 林漢翔(Han-Shiang Lin) ； 何健章(Chien-Chang Ho) ； 曾慶裕(Ching-Yu Tseng)

《兩岸運動訓練科學研討會論文集》 2011 (2012/01) Pp. 121-126

https://doi.org/10.30004/YDSCIENCE.201201.0121

摘要

代謝症候群會促進動脈粥狀硬化的形成，進而增加心血管疾病的罹病率與死亡率。近年來許多研究指出代謝症候群與體內慢性發炎反應有密切的相關性。但關於規律運動與發炎反應、代謝症候群的相關性依然尚未釐清。因此，本研究目的在探討規律運動與發炎反應指標－C反應蛋白（C-reactive protein, CRP）、代謝症候群及其組成因子的相關性。本研究係以「冠狀動脈心臟病危險因子調查資料庫」進行次級資料分析，該研究設計係以醫院為基礎的病例對照研究（hospital-based case-control study），以西元2003年1月至12月台灣中部地區一所醫學教學中心－台中榮民總醫院健檢部門所募集473位健康受試者為研究對象。依受試者每週是否從事規律運動行為分成二組：運動組（n=285）與非運動組（n=188），對其體位評估、血壓量測、血液生化檢測及生活習慣（抽菸狀況、酒精攝取、運動情形及營養補充劑攝取頻率情形）等資料，作描述性統計及以獨立樣本t檢定、卡方檢定、皮爾森淨相關和多變項線性迴歸模式進行資料分析。結果顯示運動組的高敏感度C-反應蛋白（hs-CRP）濃度為0.14 ± 0.23 mg/dL，非運動組為0.17 ± 0.37mg/dL，兩組之間並無顯著性的差異（p ＞ 0.05）。利用多變項線性迴歸分析調整相關因子後，結果發現規律運動與hs-CRP濃度的迴歸係數（β=-0.0333, p=0.2228）。運動組與非運動組的代謝症候群（4.56%及4.26%）、腹部肥胖（28.07%及28.19%）、血壓上升（14.04%及19.68%）、高密度脂蛋白膽固醇過低（8.42%及11.17%）及三酸甘油酯上升（27.72%及24.47%）的盛行率，兩組間沒有顯著性的差異（p＞ 0.05）。本研究結論出，從事規律運動與發炎反應、代謝症候群及其指標沒有相關。未來研究應針對運動項目、強度、頻率和時間進行紀錄與定量，進一步釐清其關係。

關鍵字

規律運動 ； 發炎反應 ； 高敏感度-C反應蛋白 ； 代謝症候群

並列摘要

Metabolic syndrome (MS) is a condition that promotes atherosclerosis and increases the risk of cardiovascular morbidity and mortality. Recent studies have shown an association between the MS and chronic subclinical inflammation, as determined by elevated C-reactive protein (CRP). However, the effects of regulate exercise on inflammation and MS are still uncertain. The purpose of this study was to evaluate the relationship between self-reported regulate exercise status, inflammation, and MS after taking into account the potential confounders. The secondary database was obtained from the Risk Factor of Coronary Artery Disease Survey in Taiwan. The healthy individuals were recruited from the physical examination unit of Taichung Veterans Hospital and they exhibited normal blood biochemical values. These subjects were divided into two groups: exercise group (n=285) and non-exercise group (n=188). The distribution of subjects’ demographic data, anthropometric indices, and biochemical measurements between exercise and non-exercise groups were analyzed. Subjects in the exercise group had non-significantly lower values for hs-CRP concentrations than in the non-exercise group. The multiple regression results showed that with the non-exercise group as the baseline, the effect of exercise group (β=-0.0333, p=0.2228) was non-significantly and negatively associated with hs-CRP concentration after adjusting for potential confounders. There was no significant difference in the prevalence of MS and its components between exercise and non-exercise groups. Our findings suggested that regulate exercise did not produce a significant differences in hs-CRP concentration and prevalence of the MS in a healthy population.

並列關鍵字

regulate exercise ； inflammation ； high sensitivity C-reactive protein ； metabolic syndrome