評估三株益生菌對高脂飲食肥胖大鼠體脂肪、體重及血液生化值的影響

Effect of Three Probiotic Strains on Body Fat, Body Weight and Blood Biochemical Profiles in High-fat Diet-induced Obese Rats

石仰慈(Yang-Tzu Shih) ； 林詩偉(Shih-Wei Lin) ； 陳炎鍊(Yen-Lien Chen) ； 徐慶琳(Chin-Lin Hsu) ； 陳勁初(Chin-Chu Chen)

《檢驗及品保雜誌》 9卷2期 (2020/04) Pp. 73-81

https://doi.org/10.6573/JTQA.202004_9(2).03

摘要

本研究以屎腸球菌GK43、羅伊氏乳酸桿菌GKR1及副乾酪乳酸桿菌GKS6三株益生菌粉末餵食高脂飲食誘導肥胖之Wistar大鼠，評估三株益生菌株對體脂肪、體重及血液生化值的影響。試驗大鼠分為五組，分別正常組（ND）餵食正常飼料，高脂飼料組（HFD）及高脂飼料給予不同株益生菌組（HFD+GK43、HDF+GKR1 及HDF+GKS6）。結果顯示每日給予副乾酪乳酸桿菌GKS6效果最佳，在抑制體重增加、肝腫大、內臟脂肪與體脂肪堆積與血清三酸甘油酯（triglyceride, TG）及脂肪油滴細胞大小皆有達到顯著差異（p＜0.05）。

關鍵字

副乾酪乳酸桿菌GKS6 ； 益生菌 ； 肥胖 ； 體脂 ； 三酸甘油酯

並列摘要

This study was aimed to investigate the effects of three probiotic strains (Enterococcus faecium GK43, Lactobacillus reuteri GKR1, and Lactobacillus paracasei GKS6) on body fat, body weight, and blood biochemical profiles of Wistar rats fed with high fat diet. The rats were randomly divided into five groups: normal diet (ND), high-fat diet (HFD), high-fat diet with GK43 (HFD+GK43), high-fat diet with GKR1 (HFD+GKR1), and high-fat diet with GKS6 (HFD+GKS6) groups. Results showed that daily administration of the probiotics reduced high-fat diet-induced weight gain and that the strain GKS6 was most effective in reducing body and liver weight, visceral and body fat, and serum triglyceride levels in rats (p＜0.05).

並列關鍵字

Lactobacillus paracasei GKS6 ； probiotics ； obesity ； body fat ； triglyceride