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液相層析質譜儀介面技術及應用

Liquid Chromatography/Mass Spectrometry Techniques and Applications

摘要


LC/MS 主要是用來解決GC/MS 無法分析的樣品,如熱不穩定、低揮發性和高極性化合物。而LC/MS介面是近幾十年才發展出來,包括液相直接導入介面、機械傳送介面、熱灑法、粒子束介面、電灑法和離子灑法。本文僅對各種介面的設計、其使用上之優缺點以及LC/MS在各種領域上之應用做一簡單介紹。

並列摘要


LC/MS has been proposed to solve the problem of the inability of conventional GC/MS to analyze molecules considered either thermally labile of low volatility or high polarity. Over the last decade, many techniques including direct liquid introduction interfaces, mechanical transport dev ices, thermospray, particle beam interfaces, electrospray and ionspray have evolved to find practical application in LC/MS. For direct comparision of these different methods, a number of important criteria can facilitate the discussion of their relative strengths and weakness, the structure, eluant capacity, and choice of ionization method. The applications of LC/MS are also introduced.

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