四極距磁共振光譜的研究與應用─管制物質的鑑識分析

The Development and Application of Nuclear Quadrupole Resonance: Chemical Analysis of Targeted Drugs

張白青(B.-C. Chang) ； 李文凡(W.-F. Lee) ； 李豐穎(F.Y. Li) ； 廖明淵(M.-Y. Liao)

《化學》 63卷2期 (2005/06) Pp. 177-183

https://doi.org/10.6623/chem.2005013

摘要

高磁場核磁共振分析技術發展至今，已經被各科技領域所廣泛使用，舉凡材料的物性分析，分子的結構鑑定，實體的影像分析等均有相當大的貢獻。然而，對於絕大部分（約75%）具四極距之核種在零磁場下的研究並不多。主要因素乃在於零磁場下各核子共振頻率則是無法掌握的，即使是相同的原子核，共振頻率隨其外在環境不同，可能產生很大的差異，加上其靈敏度也相對較低，致使四極距磁共振分析技術的發展與應用受到限制。但四極距磁共振的選擇性很高，各種物質中的四極距核種均具有其特性光譜，宛如物質的指紋。因此，可以很容易地提供特殊管制物質的檢測方法，對於化學分析技術應用有很大助益。本報告本著理論與實驗並行，期望建立各種特定管制藥物（如安非他命、甲基安非他命、搖頭丸、K他命等）的四極距核種特性光譜資料庫，最後以四極距磁共振檢測法，提供鑑識科學的特殊應用。

關鍵字

化學分析 ； 管制物質 ； 四極距磁共振分析

並列摘要

Nuclear Magnetic Resonance Spectroscopy has been a powerful tool for scientific research, such as the characterization of materials, molecular structures and imagining. However, these modern NMR techniques for the high field are not applied extensively to the cases of quadrupole nuclei in zero field which is conventionally called NQR. The main reason is that the resonance frequency of the objective nucleus is usually unknown and hard to predict since it is very sensitive to the local environment. NQR spectra usually exhibit the characteristic resonance frequencies of materials, which behave as the fingers prints of materials and can be applied for chemical analysis. The important question of how to obtain the NQR information of such materials remains to be answered. In this report, NMR of quadrupole nuclei and its application for the detection of targeted drugs (such as amphetamine, methyl amphetamine, MDMA and Special K) will be discussed.

並列關鍵字

Chemical Analysis ； Targeted Drugs ； NQR Analysis