奈米光感藥物傳輸

光動力治療(photodynamic therapy; PDT)是一種目前被醫學界認可的低侵入性治療方法，可應用於皮膚表面的病灶或是皮表的癌症做局部性的治療。醫學界已使用許多的光感藥物應用於癌症治療，但由於藥物具有水溶性不佳、選擇性低等缺點，造成抗癌效果不彰或是副作用的產生。本文章在介紹利用奈米載體與光動力醫學結合後的效能，包括增強光動力治療效率，或是解決化療藥物之副作用等。

關鍵字

光動力治療；光動力診斷；奈米載體；皮膚光敏性

並列摘要

Photodynamic therapy (PDT) is a low-invasive method for cancer treatment or other skin diseases. Important advantages of PDT over other therapies include the ability to deliver a precisely targeted treatment through selective illumination, the potential for repeated application at the same site if needed. However, the biodistribution of photosensitizers is unfavorable and phototoxicity to the skin, mainly caused by an agent’ hydrophobicity and non-selectivity, is a considerable limitation of their use. In this article, the potential of photosensitizer-loaded nanocarrier, including the enhancement of PDT efficacy and the reduction of the side effects of PDT, was discussed.

並列關鍵字

Photodynamic therapy ； Photodynamic diagnosis ； Nanocarrier ； Skin photosensitivity

國際替代計量

奈米光感藥物傳輸

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