製備金奈米複合載體及利用近紅外光雷射控制其在藥物傳輸之應用

Preparation of Gold Nanocomposites as Drug Carriers and Their Application in the Release of Drug Triggering by Near-infrared Laser

趙育慶(Yu-Ching Chao)

指導教授 ： 陳家俊

國立臺灣師範大學/理學院/化學系/碩士(2007年)

摘要

本文是製備包覆多層高分子之金奈米棒（GNRs-MLP）來作為藥物載體。我們將包覆 paclitaxel 的金奈米複合材料載體加入人類乳癌細胞 MCF-7 中，再以近紅外光飛秒雷射照射，會發現細胞的增殖受到藥物抑制，由 MTT assay 結果證實 paclitaxel 也可經由這種機制釋放出來。因此我們認為這種金奈米複合材料載體在藥物傳輸上極具潛力。

關鍵字

金奈米複合載體 ； 藥物傳輸

並列摘要

In this work, we have been prepared gold nanorods coated with polymer as drug reservoirs. We found that when the drug carriers were exposed to femto-second NIR, the multilayer structure was expanded and paclitaxel was released. After the drug carriers were added to MCF-7 cells, MTT assay shows that the drug carriers combined with NIR irradiation allow the induction of paclitaxel in MCF-7 cells and inhibit the cell growth. We think the gold nanocomposites as nanocarriers have potentiality in drug delivery.

參考文獻

[2] C. de las H. Alarco?n; S. Pennadam; C. Alexander Chem. Soc. Rev., 2005, 34, 276–285

[10] Liu, M. Z.; Guyot-Sionnest, P. J. Phys. Chem. B. 2004, 108, 5882-5888

[11] Brioude, A.; Jiang, X. C.; Pileni, M. P. J. Phys. Chem. B. 2005, 109, 13138-13142

[12] Eustis, S.; El-Sayed, M. J. Phys. Chem. B. 2005, 109, 16350-16356

[23] Zahr, A. S.; Pishko, M. V. Biomacromolecules 2007, 8, 2004-2010