磁場誘導藥物控制釋放之載體設計

Drug Carrier Design for Magnetically-induced Controlled Release

詹宗桂(Tsung-Kui Chan) ； 鍾宜璋(Yi-Chang Chung)

《化學》 68卷3期 (2010/09) Pp. 203-213

https://doi.org/10.6623/chem.2010019

摘要

經由外部的刺激藥物控制釋放的方式有許多，其中磁力誘導是個不錯的選擇，磁力是一種非侵入性的力量不會對人體造成傷害。本文介紹一些奈米磁性載體、磁性材料結合智慧凝膠等方式，及其應用磁力控制粒子及藥物作用的範例。運用磁性奈米粒子的高表面積及超順磁特性，得以設計出多樣的藥物控制釋放載體，已在許多疾病治療上展現優勢，利用磁性殼層設計更可增加藥物載運量。此外由其磁性奈米粒子與智慧凝膠的整合，像是磁熱敏感之藥物載體可兼用磁熱療法達到腫瘤標靶治療；而利用磁場誘導可製作組織培養或修復醫學的細胞生長平台。磁性水凝膠(ferrogels)在設計上增加了熱敏感材料的穩定性以及對磁場敏感可快速作出反應，運用在藥物控制釋放可達到On-Off的控制，增加釋放模式的變化。這些磁性藥物載體展現了在未來將是非常有潛力的藥物控制釋放系統。

關鍵字

磁性奈米粒子 ； 藥物載體 ； 標靶治療 ； 藥物控制釋放 ； 智慧材料 ； 磁性水凝膠

並列摘要

There are plenty of controlled release drugs stimulated from outside. Magnetic induction should be a nice choice due to its non-invasive and less harmful property, comparing with other stimuli resources, such as electric field, lighting, heating, and so forth. In this review we introduce some magnetic nanocarriers and magnetic particles come with intelligent gels, as well as their particle control and mechanisms achieved by magnetic induction. By using the high surface area property and superparamagneticity of magnetic nanoparticles, there have been many controlled release drug designed for variety medical uses and clinical applications. A design of magnetic nanoshell have been also employed to enhance the drug load. As for the magnetic nanoparticles combined with intelligent gels, such as magnetically and thermally sensitive carriers have been used in targeting therapy through hyperthermia cancer treatment. On the other hand, the gels can be formed by magnetic control and as a cell platform for the applications of tissue incubation and reparative medicine. Ferrolgels added with thermally-sensitive gels can increase their stability and also can perform a rapid response to magnetic changes to display their excellent on-off states and various releasing types. All the examples show their potential to benefit the controlled release drug system in the near future.

並列關鍵字

Magnetic nanoparticles ； Drug carriers ； Targetingtherapy ； Controlled release drug ； Intelligent materials ； Ferrogels