雙性聚醣高分子於生醫及藥物載體上之應用

Amphipathic Polysaccharides for Biomedical and Drug Carriers Applications

劉定宇(Ting-Yu Liu) ； 黃皪瑩(Li-Ying Huang) ； 劉昆和(Kun-Ho Liu) ； 楊銘乾(Ming-Chien Yang) ； 簡雄飛(Hsiung-Fei Chien) ； 戴念梓(Niann-Tzyy Dai) ； 劉澤英(Tse-Ying Liu) ； 陳三元(San-Yuan Chen) ； 劉典謨(Dean-Mo Liu)

《化學》 71卷1期 (2013/03) Pp. 33-44

https://doi.org/10.6623/chem.2013004

摘要

本文將針對新型之雙性聚醣高分子之合成特性及其在生物醫學及藥物載體之應用做一統整性之整理。由幾丁聚醣做親疏水化學改質之雙性幾丁聚醣(凱索尼®酸)預期將有下列幾項優點：(1)具有高度吸水與保濕效果(可媲美玻尿酸)：可避免組織液回流於皮膚內造成組織沾黏；(2)藉由靜電紡絲所形成之奈米纖維，具有孔洞多、比表面積大之特性，其對於吸水及保濕性更有加乘的效果；(3)具備溫度敏感性：其接觸皮膚後(~37°C)，會有緊縮的效果，可增加組織之自由體積，降低組織沾黏之可能性；(4)殘留之NH2官能基，經過初步測試，仍然保有相當程度之凝血及抗菌效果；(5)釋放藥物之功能：其能自組裝成中空奈米膠囊並包覆藥物(抗發炎或抗纖維化藥物)，可加速傷口癒合避免疤痕產生；(6)結構與性質可調控性佳：根據不同需求可以改變親疏水官能基的比例，因此可調控其吸水性、保濕性及溫度敏感性，將成為凱索尼®酸之最大之競爭力，預期將可成為先進生醫材料之明日之星。

關鍵字

雙性聚醣高分子 ； 凱索尼酸 ； 創傷敷料 ； 奈米纖維 ； 藥物載體 ； 生物醫學材料

並列摘要

The characterizations of novel amphipathic polysaccharides for the applications of biomedical device and drug carriers would be summarized in this paper. The amphipathic chitosan (chitosonic® acid) were chemically-modified by pristine chitosan with varied ratio of hydrophilic/ hydrophobic group immobilization. They will exhibit the following features: (1) high water absorption and retention capacity (comparable to hyaluronic acid) that avoiding tissue adhesion; (2) high porosity and specific surface area of nanofibers made by electro-spun that enhancing the water absorbability and retention capacity; (3) thermal sensitivity that reducing further the tissue adhesion due to shrinking on contacting skin (~37 °C); (4) residual amino groups of chitosan that reserving anti-bacterial activity and thrombogeneicity; (5) ability of encapsulating drugs via selfassembling nano-capsules that serving as controlled release vehicle to enhance the wound healing and avoid scar formation; (6) controllable properties such as water absorbability, water retention capacity, and temperature sensitivity via adjusting chemical structure of hydrophilic/hydrophobic group immobilization. With these advanced features, this novel chitosonic® acid would be very competitive in the field of advanced biomedical materials.

並列關鍵字

Amphipathic polysaccharides ； Chitosonic acid ； Wound dressing ； Nanofibers ； Drug carriers ； Biomedical materials