奈米生醫光電：表面增強拉曼散射應用於分子檢測與分子影像

Nanobiophotonics: Surface Enhanced Raman Scattering (SERS) on Molecular Sensing and Imaging

李健瑋(Chien-Wei Lee) ； 黃志嘉(Chih-Chia Huang)

《化學》 74卷1期 (2016/03) Pp. 21-31

https://doi.org/10.6623/chem.2016003

摘要

「表面增強拉曼散射光譜」在近年來有突破性的發展與應用，此篇文章將介紹拉曼的歷史背景與原理，並且簡述「貴金屬奈米材料」利用表面電漿共振來放大拉曼訊號的機制（電磁與化學效應）。此外本文亦介紹近年來「表面增強拉曼散射光譜」相關應用，例如分子檢測以及分子影像，最後介紹功能性拉曼技術應用於協助光治療或是多重影像顯影系統。

關鍵字

表面增強拉曼散射 ； 奈米粒子 ； 分子檢測 ； 分子影像 ； 診斷與治療

並列摘要

Surface enhanced Raman scattering (SERS) spectrum has received considerable attention in recent years because SERS technology can be developed and applied for sensing molecules and performingbio-imaging tracking analysis method. In this article, we provide a brief introduction to the core concepts ofthe SERS evolution and itspotential applications when the SERS technology combined with nano-sized particles. Interestingly, surface plasmon resonance of noble metal nanoparticles greatly assists the promotion of SERS effect. The induction of the SERS generation around noble metal nanoparticles can perform vibration signal generation locally in biological and environment specimensystems. The relevant examples (e.g., toxic molecule sensing, SERS mapping method for molecular imaging, SERS-combined phototherapy, and multi-model optical imaging system) in the current reports are included.

並列關鍵字

Surface enhanced Raman scattering ； Nanoparticles ； Molecular sensing ； Molecular imaging ； Theranostics