Fluorescent metal nanoclusters including gold nanoclusters, silver nanoclusters and copper nanoclusters have attracted much attention in many fields because of their molecule-like optical properties, strong fluorescence and good biocompatibility. In recent years, those metal nanoclusters also show wide applications in chemiluminescence analysis by act as catalysts or energy acceptor. In this mini review, we summarize the metal nanoclusters from the viewpoints of synthesis and recent applications in chemiluminescence analysis. Finally, brief summary and future challenges are included.