MSG 對5'-IMP所引起雄性大白鼠攝食及攝水之影響

Effect of MSG on the 5'-IMP Induced Food and Water Intake in Male Rats

楊齊生(Jimmy Chi-Sheng Yang) ； 林佩珊(Pei-Shan Lin) ； 陳靜雯(Ching-Wen Chen) ； 陳美娥(Mei-E Chen) ； 王慧如(Hui-Ju Wang)

《弘光學報》 42期 (2003/11) Pp. 33-38

https://doi.org/10.6615/HAR.200311.42.04

摘要

東方世界中，中國大陸、日本、韓國等國家，尤其是在台灣，人們烹調過程中非常喜愛使用人士添加物味精，近年來高鮮味精也越來越受家庭烹調所歡迎。然而高鮮味精含有味精(monosodium glutamate, MSG) 及核苷酸(ribonucleotide)類的inosine-5'-monophosphate (5'-IMP)和guanosine -5'-monophosphate (5'-GMP)，此類物質均可產生一特定味覺- Umami。因此本次實驗針對高鮮味精其中成分對雄性大白鼠的攝食攝水之影響，並且以腦腔注射(Intracerebroventricular，ICV)直接注入5'-IMP以研究其對中樞調控攝食之影響，實驗(一)針對MSG對由5'-IMP所引起之攝食行為影響，結果顯示0.2% MSG有顯著抑制由5'-IMP所引起之攝食行為：實驗(二)利用連續兩天每日以ICV注射0.01 P mole 5'-IMP，對於SD雄性大白鼠攝食量與注射saline之對照組比較並無顯著性之差異。因此由本次實驗結果得知，我們推論0.2%MSG有顯著抑制由5'-IMP引起食慾的作用，但並無直接證據證明5'-IMP增加攝食量是直接作用於中樞神經。

關鍵字

攝食

並列摘要

Monosodium glutamate (MSG) is a popular food additive in Taiwan. Recently, super seasoning containing MSG, 5'-GMP and 5'-IMP, becomes popular in cooking. To understand the mechanism of these molecules in enhancing food flavor and appetite, we designed two experiments and found that (1) oral treatment of MSG inhibited the increase in food intake induced by 5'-IMP; (2) 0.01pmole of 5'-IMP administered intracerebroventricularly did not affect food intake in adult male rats. In conclusion, MSG may play a role in attenuating the increasing feeding induced by 5'-IMP. There is no evidence to show that 5'-IMP directly affects the feeding of rats through the central nerve system.

並列關鍵字

5'-IMP ； MSG ； ICV ； food intake

參考文獻

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