Effects of multistrain lactic acid bacteria with probiotic properties on enhancements of IgA, IgG levels and anti- Salmonella Typhimurium invasion activity

具益生菌特性之多重乳酸菌對提昇IgA, IgG和抗沙門氏菌侵入活性之影響

何承穎(Cheng-Ying Ho) ； 陳俊曄(Chun-Yeh Chen) ； 陳玉枝(Yu-Chih Chen) ； 蔡政志(Cheng-Chih Tsai)

《弘光學報》 63期 (2011/06) Pp. 156-173

https://doi.org/10.6615/HAR.201106.63.11

摘要

本研究連續28天管餵BALB/c小鼠多重益生菌或無菌水。在第4週，口服益生菌的小鼠，其血清中免疫球蛋白總IgA和IgG抗體濃度顯著高於控制組(p＜0.05)。餵食多重益生菌28天後，可明顯增加糞便中雙歧桿菌及乳酸桿菌之菌量(p＜0.05)。另一個動物模型為連續餵食小鼠14天。在第7天給予所有小鼠鼠傷寒沙門氏菌ISM50。為期6天的感染後犧牲小鼠，發現餵食過益生菌的小鼠，其脾臟和肝臟中之沙門氏菌菌數與控制組相較有顯著下降 (p＜0.001)。我們證明多重益生菌可以提高老鼠血清IgA和IgG的含量，並預防沙門氏菌之感染。

關鍵字

益生菌 ； 免疫球蛋白 ； 沙門氏菌侵入

並列摘要

In our study, BALB/c mice were orally administered multistrain probiotics or sterile water for 28 consecutive days. The total serum IgA and IgG antibody levels were significantly higher in the group of mice administered probiotics (p ＜ 0.05) than in the control group at the 4^(th) week. Consumption of multistrain probiotics for 28 days significantly increased (p ＜ 0.05) the fecal populations of Bifidobacterium spp. and Lactobacillus spp. In another animal model, the mice were orally administered for 14 consecutive days. On the 7th day, all the mice were orally challenged with Salmonella Typhimurium ISM 50. The mice were sacrificed after 6 days of infection, Salmonella counts in the spleen and liver of the mice administered probiotics significantly declined (p ＜ 0.001) as compared to the control group. We demonstrated that the probiotic mixture could be used to enhance the host serum IgA and IgG levels and prevent Salmonella infection.

並列關鍵字

Probiotics ； immunoglobulin ； Salmonella invasion

參考文獻

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