專論：維生素D對新冠肺炎之效益

A Mini-Review: the Effects of Vitamin D on COVID-19

蘇裕盛(Su Yu-Sheng) ； 盧慧俐(Lu Hui-Li)

《弘光學報》 89期 (2022/03) Pp. 1-17

https://doi.org/10.6615/HAR.202203_(89).0001

摘要

本文旨在探討維生素D（Vitamin D, VD）對於新冠肺炎（Coronavirus disease 2019, COVID-19）的效益，特別是闡述VD可降低COVID-19感染的風險、病症嚴重程度及其他併發症等。VD可經由多種機制以降低急性呼吸道感染和COVID-19的風險，例如降低病毒的複製、減少促發炎細胞因子的生成、調控腎素-血管收縮素系統（Renin-angiotensin system, RAS）、平衡血管收縮素轉換酶（Angiotensin-converting enzyme, ACE）和血管收縮素轉換酶2（Angiotensin-converting enzyme 2, ACE2）、保持細胞間隙的完整性等。雖已有研究指出，補充VD可以預防或緩解COVID-19病症，但仍需更多隨機對照研究來證實它的效益性。

關鍵字

維生素D ； COVID-19 ； 新冠肺炎

並列摘要

This review article aims to evaluate the effects of vitamin D (VD) on Coronavirus disease 2019 (COVID-19), especially, to analyze its potential roles in mitigating the infection risk and disease severity of COVID-19, and its complications. Proposed mechanisms of VD include decrease in replication of viruses, reduction in production of inflammatory cytokines, regulation of renin-angiotensin system (RAS), balance between angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2), and maintenance of cell-cell junction integrity. There are several studies suggesting that VD supplementation may be effective in the prevention or treatment of COVID-19. However, the clinical consensus on the effects of VD supplementation for COVID-19 still needs more support from the randomized controlled trials.

並列關鍵字

vitamin D ； COVID-19 ； coronavirus disease-2019

參考文獻

Ahn, D. G., Shin, H. J., Kim, M. H., Lee, S., Kim, H. S., Myoung, J., Kim, B. T., & Kim, S. J. (2020). Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19) [Journal Article; Review]. J Microbiol Biotechnol, 30(3), 313-324. http://doi.org/10.4014/jmb.2003.03011

Ali, N. (2020). Role of vitamin D in preventing of COVID-19 infection, progression and severity [Journal Article; Review]. J Infect Public Health, 13(10), 1373-1380. http://doi.org/10.1016/j.jiph.2020.06.021

Annweiler, C., Cao, Z., & Sabatier, J. M. (2020). Point of view: Should COVID-19 patients be supplemented with vitamin D? [Journal Article; Review]. MATURITAS, 140, 24-26. http://doi.org/10.1016/j.maturitas.2020.06.003

Annweiler, C., Hanotte, B., Grandin, D. L. C., Sabatier, J. M., Lafaie, L., & Celarier, T. (2020). Vitamin D and survival in COVID-19 patients: A quasi-experimental study [Journal Article]. J Steroid Biochem Mol Biol, 204, 105771. http://doi.org/10.1016/j.jsbmb.2020.105771

Aranow, C. (2011). Vitamin D and the immune system [Journal Article; Research Support, N.I.H., Extramural; Review]. J Investig Med, 59(6), 881-886. http://doi.org/10.2310/JIM.0b013e31821b8755