Estimation of Duration of Symptoms in Fulminant Type 1 Diabetes Mellitus Using HbA_(1c) or Glycated Albumin

Akitsu Kawabe ； Takashi Seta ； Sumie Fujii ； Masayo Yamada ； Shogo Oki ； Jun Murai ； Hiroshi Saito ； Masafumi Koga

《Japanese Clinical Medicine》 2012 (2012/12) Pp. 15-20

https://doi.org/10.4137/JCM.S9509

並列摘要

Fulminant type 1 diabetes mellitus (FT1DM) develops as a result of very rapid and almost complete destruction of pancreatic β cells. Because of an abrupt increase in plasma glucose, HbA_(1c) and glycated albumin (GA) might increase along with duration of symptoms in FT1DM patients. We attempted to devise a formula to estimate duration of symptoms based on the increased levels in HbA_(1c) or GA. Four patients who developed FT1DM during the course of type 2 diabetes mellitus and in whom HbA_(1c) was measured before onset were investigated in this study. The percents of the estimated duration of symptoms calculated from HbA_(1c) (four patients) and GA (two patients) to the actual duration were 137 ± 88% and 122%, respectively. In FT1DM patients in whom HbA_(1c) and/or GA before onset and at the time of ketoacidosis are measured, duration of symptoms might be estimated with using the increased levels in HbA_(1c) or GA.

並列關鍵字

HbA_(1c) ； glycated albumin ； fulminant type 1 diabetes mellitus