- 期刊
- OpenAccess
Urinary Excretion of Phenolic Acids by Infants and Children: A Randomised Double-Blind Clinical Assay
並列摘要
Objectives: The present study, which is part of the ISRCTN16968287 clinical assay, is aimed at determining the effects of cranberry syrup or trimethoprim treatment for UTI. Methods: This Phase III randomised clinical trial was conducted at the San Cecilio Clinical Hospital (Granada, Spain) with a study population of 192 patients, aged between 1 month and 13 years. Criteria for inclusion were a background of recurrent UTI, associated or otherwise with vesico-ureteral reflux of any degree, or renal pelvic dilatation associated with urinary infection. Each child was randomly given 0.2 mL/Kg/day of either cranberry syrup or trimethoprim (8 mg/mL). The primary and secondary objectives, respectively, were to determine the risk of UTI and the levels of phenolic acids in urine associated with each intervention. Results: With respect to UTI, the cranberry treatment was non-inferior to trimethoprim. Increased urinary excretion of ferulic acid was associated with a greater risk of UTI developing in infants aged under 1 year (RR 1.06; CI 95% 1.024- 1.1; P = 0.001). Conclusions: The results obtained show the excretion of ferulic acid is higher in infants aged under 1 year, giving rise to an increased risk of UTI, for both treatment options.
延伸閱讀
- Tsai, C. H., Cheng, C. L., Lin, Y. J., Liu, C. C., Yang, Y. H. K., & Lin, C. H. (2005). Effects of Fluconazole Prophylaxis against Systemic Fungal Infection in Extremely-low-birth-weight Infants. Clinical Neonatology, 12(1), 6-12. https://doi.org/10.7098/CN.200507.0006
- 易瑜嶠（2011）。Evaluation of Clinical Significances of Serum Autoantibodies and Genomic Polymorphisms inEndometrium –related Diseases〔博士論文，中山醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0003-1108201121363700
- Pacifici, G. (2014). Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review. International Journal of Pediatrics, (2014), 274-293. https://doi.org/10.1155/2014/309342
- Shen, E. Y., Lai, Y. J., Ho, C. S., & Lee, Y. L. (1999). Excitatory and Inhibitory Amino Acid Levels in the Cerebrospinal Fluids of Children with Neurological Disorders. Acta Paediatrica Sinica, 40(2), 65-69. https://doi.org/10.7097/APS.199904.0144
- Nakajima, Y., & Masaoka, N. (2014). Evaluation of Creatine Kinase, Lactate Dehydrogenase, and Amylase Concentrations in Umbilical Blood of Preterm Infants after Long-Term Tocolysis. Obstetrics and Gynecology International, (2014), 52-59. https://doi.org/10.1155/2014/278379