Excitatory and Inhibitory Amino Acid Levels in the Cerebrospinal Fluids of Children with Neurological Disorders

吾人體內的一部份氨基酸爲中樞神經傳遞物質的重要成員之一，分佈在中樞神經的各區域並參與神經元的活動。而依其在中樞神經的作用，可分爲興奮性及抑制性氨基酸。其中較重要的氨基酸包括麩胺酸(Glutamate)，天門冬胺酸(Aspartate)，甘胺酸(Glycine)，胺基乙磺酸(Taurine)及胺基丁酸(GABA)等。文獻報告這些氨基酸在腦脊髓液中的濃度可因不同的神經疾患而改變。近來藉著高效液相層析儀(HPLC)的發展，吾人可以定量測出這些氨基酸在腦脊髓液中的微量變化，作爲臨床觀察病程的參攷。本研究依據高效液相層析儀對病患的腦脊髓液對氨基酸濃度的測定。發現麩胺酸的濃度在細菌性、無菌性腦膜炎及腦炎病人有明顯昇高，天門冬胺酸在細菌性腦膜炎及痙攣病人昇高。甘胺酸在細菌及無菌性腦膜炎病人昇高，胺基乙酸在細菌性腦膜炎及腦炎病人昇高，胺基丁酸在腦炎病人明顯昇高。本實驗顯示此等氨本酸濃度會因不同的疾患而改變。因此我們建議作更多的實驗來分析，以明瞭各種不同的疾病在各種不同的病程中，各胺基酸的變化，及兒童各年齡層間的差異，以期可以做爲未來臨床診斷疾病與觀察病程的參攷。

關鍵字

與奮性胺基酸；抑制性胺基酸；腦膜炎；腦炎；痙攣

並列摘要

Measurement of amino acid levels in the cerebrospinal fluid (CSF) of children with various neurological disorders was performed with high performance liquid chromatography (HPLC). Glutamate increased in patients with bacterial meningitis, aseptic meningitis and encephalitis. Aspartate increased in bacterial meningitis and seizure disorders. Glycine increased in both bacterial and aseptic meningitis. Taurine increased in bacterial meningitis and encephalitis. GABA, the main inhibitory amino acid, increased in encephalitis. Excitatory and inhibitory amino acids are richly distributed in brain tissue and are related to neuron activity. Changes in amino acid levels in the CSF may reflect the pathologic state and severity of brain insults, and may be useful in monitoring disease processes. Further study is necessary to determine whether CSF aminos acid levels have a role in practical clinical application.

並列關鍵字

excitatory amino acids ； inhibitory amino acids ； meningitis encephalitis ； seizure

國際替代計量

Excitatory and Inhibitory Amino Acid Levels in the Cerebrospinal Fluids of Children with Neurological Disorders

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