Impact of Controlled Ovarian Hyperstimulation on Thyroid Function

Kathrin Fleischer ； Alex F. Muller ； Femke P. Hohmann ； Frank H. de Jong ； Marinus J.C. Eijkemans ； Bart C. Fauser ； Joop S.E. Laven

《Reproductive Biology Insights》 2014期 (2014/12) Pp. 9-16

https://doi.org/10.4137/RBI.S13450

並列摘要

OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E_2), thyroxine binding globulin (TBG), free thyroxine (FT_4), total thyroxine (TT_4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E_2, TBG, and TT_4 were significantly higher; midluteal FT_4 was significantly lower (mean difference: -1.46 pmol/L; P＜ 0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4 and higher midluteal TSH levels compared to the natural cycle.

並列關鍵字

ovarian hyperstimulation ； thyroid function ； neurodevelopmental delay ； Assisted Reproductive Technology (ART)