- 期刊
- OpenAccess
Effect of Chronic Hepatitis C Virus Treatment by Combination Therapy on Cardiovascular System
摘要
BACKGROUND: The prevalence of hepatitis C virus (HCV) in Egypt is quite high, and the combined oral direct-acting antiviral agents (DAAs) may have impressive results. OBJECTIVE: To assess the cardiovascular effects of DAAs in patients with HCV. METHODS: A total of 170 patients with HCV were divided into 2 groups: first group (100 patients) received triple combination therapy (pegylated interferon alfa, sofosbuvir, and ribavirin, whereas the second group (70 patients) received dual combination therapy (sofosbuvir and simeprevir). Group 1 patients were followed up for 1 year more than 3 visits, whereas group 2 patients were followed up for 6 months more than 2 visits; and the end point of the study was the development of a major cardiovascular event (eg, congestive heart failure, echocardiographic evidence of left ventricular dysfunction, occurrence of significant arrhythmias, or acute coronary syndrome). The following parameters were accomplished: medical history and clinical examination, electrocardiogram, echo-Doppler study, and laboratory investigations. RESULTS: No significant differences were found between the 2 study groups regarding demographic criteria. None of the both group patients had developed any major cardiac event. No significant changes were observed regarding ST-T wave abnormalities, arrhythmias, or QT interval. None of the both group patients developed echocardiographic regional wall motion abnormalities at baseline or at study end. Systolic function parameters showed minute nonsignificant changes over study visits. Diastolic function parameters showed nonsignificant changes between baseline and 6-month and 12-month visits. CONCLUSIONS: The DAAs used in combination regimen with interferon or used orally in combination do not significantly affect the cardiovascular system.
延伸閱讀
- Liu, C. H. (2015). Optimizing Treatment for Chronic Hepatitis C Patients with Hepatitis C Virus Genotype 1 Infection [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2015.00064
- Poggi, G., Villani, L., Sottotetti, F., Tagliaferri, B., Montagna, B., Amatu, A., & Bernardo, G. (2009). Treatment of Chronic Hepatitis C in a Patient Affected by Systemic Sclerosis. Gastroenterology Research and Practice, 2009(), 83-87. https://doi.org/10.1155/2009/475390
- 莊萬龍、余明隆（2007）。Treatment of Chronic Hepatitis C。台灣醫學，11(5)，507-517。https://doi.org/10.6320/FJM.2007.11(5).07
- 劉俊人、賴明陽（1998）。Treatment of Chronic Hepatitis C。台灣醫學，2(6)，661-667。https://doi.org/10.6320/FJM.1998.2(6).09
- Chuang, W. L., Chang, W. Y., Lu, S. N., Lin, Z. Y., Chen, S. C., Hsieh, M. Y., Wang, L. Y., Wu, C. C., Chang, S. F., & Chow, T. Y. (1987). Hepatitis D Virus Infection in Patients with Chronic Hepatitis B Virus Infection. The Kaohsiung Journal of Medical Sciences, 3(2), 121-127. https://doi.org/10.6452/KJMS.198702.0121