摘要
肉芽腫性多血管炎（granulomatosis with polyangiitis, GPA）是系統性血管炎的一種，主要侵犯小血管。該疾病目前之病生理機轉仍不清楚，常侵犯上、下呼吸道、腎臟、神經系統、皮膚系統等。這種疾病常以非特異性系統性症狀表現，包括發燒、疲倦、食慾減退、體重下降等，因此時常被當作感染、關節炎及惡性疾病診療。透過典型器官侵犯、血清檢驗、器官切片檢驗出典型病灶達成診斷。此類疾病主要透過糖皮質素及免疫調節劑進行治療。
參考文獻
Watts RA, Mahr A, Mohammad AJ, et al. Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Nephrology Dialysis Transplantation 2015;30:i14-22.
Kitching AR, Anders H-J, Basu N, et al. ANCA-associated vasculitis. Nature Reviews Disease Primers 2020;6.
Wu CS, Hsieh CJ, Peng YS, et al. Antineutrophil cytoplasmic antibody-associated vasculitis in Taiwan: A hospital-based study with reference to the population-based National Health Insurance database. J Microbiol Immunol Infect 2015;48:477-82.
Scott J, Hartnett J, Mockler D, et al. Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review. Autoimmun Rev 2020;19:102660.
Mendel A, Ennis D, Go E, et al. CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update. J Rheumatol 2021;48:555-66.
延伸閱讀
- Chen, H. C., Yang, K. D., Lin, A. S., Wang, C. C., Huang, W. T., & Lie, C. H. (2011). 肺部肉芽性發炎及不明原因反覆感染－慢性肉芽腫病個案報告. 胸腔醫學, 26(3), 133-139. https://doi.org/10.29806/TM.201106.0003
- 江侑洵、趙恒勝（2022）。胸腔病例（三九一）氣管內良性腫瘤－纖維上皮息肉。臨床醫學月刊，90(5)，750-752。https://doi.org/10.6666/ClinMed.202211_90(5).0124
- 吳佳儒、江起陸（2020）。胸腔病例（三六六）肺動靜脈畸形。臨床醫學月刊，85(5)，316-321。https://doi.org/10.6666/ClinMed.202005_85(5).0056
- 沈易綸、陳穎瑩、賴信良（2018）。胸腔病例（三五二）肺錯構瘤。臨床醫學月刊，82(3)，558-561。https://doi.org/10.6666/ClinMed.201809_82(3).0102
- 孫傳硯、陽光耀（2021）。胸腔病例（三八二）隱源性組織化肺炎。臨床醫學月刊，88(5)，731-734。https://doi.org/10.6666/ClinMed.202111_88(5).0123