Neuromuscular Interactions between Succinylcholine and Esmolol in the Rat

Succinylcholine和Esmolol神經肌肉作用在大白鼠的研究

鄭榮耀(Rong-Yaw Chang) ； 陳水城(Shoei-Cherng Chern) ； 曾慶暉(King-Fui Tseng) ； 江永源(Yung- Yuan Chiang) ； 劉明德(Ming-Der Liou) ； 蔡勝國(Shen-Kou Tsai)

《Acta Anaesthesiologica Sinica》 32卷3期 (1994/09) Pp. 203-208

摘要

To study the neuromuscular interactions between succinylcholine (Sch) and esmolol, we determined the dose-response relationship of Sch and the neuromuscular actions of the 3xED_(90) dose of Sch, both prior to and following esmolol pretreatment. Twenty rats were anaesthetized with urethane. Train-of-four stimulation was applied every 12 s to the sciatic nerve, and the electromyogram (EMG) of the tibialis anterior muscle was measured. The results showed that the potency of Sch decreased with esmolol pretreatment. The ED_(50) of Sch increased significantly, from 191 ug/kg to 227 ug/kg after esmolol infusion, p＜ 0.05. The duration of EMG depression achieved by the 3xED_(90) dose of Sch decreased significantly with esmolol pretreatment (12 min vs 14 min p＜ 0.05), and also the onset time was significantly longer (43 sec vs 28 sec, p＜ 0.05). There were no significant difference between groups with regard to the maximal block or recovery index. The results of two methods of study demonstrated that the pharmacological interaction between Sch and esmolol is antagonistic instead of potentiating.

關鍵字

Succinylcholine and esmolol

並列摘要

本研究是有關於Succinylcholine（Sch）和Esmolol之間的神經肌肉作用關係，我們確定了在注射Esmolol之前和之後Sch的劑量－反應關係，並比較三倍的百分之九十有效劑量（3 x ED_(90)）的Sch在注射Esmolol之前和之後所產生的神經肌肉作用結果。二十隻用Urethane麻醉之大白鼠分成兩組，以每12秒一次的Train-of-Four（TOF）刺激器置於坐骨神經，同時記錄前脛肌之肌電圖（EMG）。結果發現在注射Esmolol後，Sch的藥效減低。Sch的百分之五十有效劑量（ED_(50)）顯現有意義的增加，從注射Esmolol之前的191μg/kg增加到注射之後的227μg/kg，P值小於0.05。自三倍ED_(90)的Sch所產生的EMG抑制亦有顯著的差異，由注射Esmolol前的14分鐘減少為12分鐘（P值小於0.05）。至於作用起始時間（onset time）在注射Esmolol後也明顯較長（43秒對28秒，P＜0.05）。至於神經肌肉最大阻斷效應（maximal block）和恢復指數（recovery index）在整個實驗中則無明顯的差異。所以此兩組的研究結果顯示：Sch和Esmolol之間的藥理反應是拮抗作用，而非加強作用。