細胞色素P450單氧酵素系統與麻醉藥物之關係

Cytochrome P450-Dependent Monooxygenase System and Anesthetics

陳大樑(Ta-Liang Chen) ； 林珍榮(Chen-Jung Lin) ； 劉健強(Chien-Chiang Liu)

《Acta Anaesthesiologica Sinica》 33卷3期 (1995/09) Pp. 185-194

摘要

細胞色素P450單氧酵素系統，負責生物體代謝內生性或外來物質之任務，對於不同藥物，此酵素群亦分別發揮物質解毒或活化之功能；近十年來，因單株抗體及免疫化學偵測法之進步，更確認了此酵素家族在代謝吸入性及靜脈麻醉劑時的重要角色，以及此酵素在催化反應上多樣性之功能。在生物體不同之生理、病理情況下，此酵素群之質與量亦會受到誘導或抑制，進而干擾生物體對其他藥物之代謝。由於麻醉藥物在體內酵素代謝過程中，常面對其他藥物之交互作用，以及個人酵素功能的差異性，故在病人體內活化或分解時，其藥物動力學、藥效及毒性亦因而受到影響，故麻醉醫師在使用麻醉藥物時，如能同時考量生物酵素系統所扮演的生化角色，必能更確切掌握藥物使用之安全性。

關鍵字

細胞色素P450酵素 ； 麻醉藥物 ； 藥物代謝 ； 毒性

並列摘要

The cytochrome P450-dependent monooxygenases constitute the primary enzyme system responsible for the oxidative metabolism of a variety of xenobiotics and endogenous compounds including drugs, carcinogens, fatty acids and hormones. The monooxygenase system consists of multiple forms of P450 enzymes, NADPH-cytochrome reductase and phospholipids. The level sof P450s and associated monooxygenase activities are subject to be regulated by many environmental, physiological, and pathological factors. Inhalation and intravenous anesthetics are all metabolized through these biotransformation enzymes. The pharmacokinetic properties as well as the toxicity of the anesthetics are closly related to the inducing or inhibitory status of the monooxygenase isozymes. To understand the role of cytochrome P450 monooxygenases in drug metabolism is essential for us to handle the drug-to-drug interactions and adverse effects.

並列關鍵字

Cytochrome P450 enzymes ； Anesthetic ； Drug metabolism ； Toxicity