動脈輸入函數對骨質疏鬆症椎體DCE-MRI定量分析的影響

The Influence of Arterial Input Function on Vertebral DCE-MRI in Osteoporosis

楊鶴廷(Hou-Ting Yang) ； 劉益瑞(Yi-Jui Liu) ； 阮春榮(Chun-Jung Juan) ； 陳榮邦(Wing P. Chan) ； 曾敬仁(Jing-Ren Tseng)

《臺灣醫事放射期刊》 10卷2期 (2022/12) Pp. 18-23

https://doi.org/10.6717/JTMRT.202212_10(2).0003

摘要

動態對比增強磁振造影（Dynamic contrast-enhanced MRI, DCE-MRI）是一種觀察微灌流特性的非侵入檢查技術，被廣泛應用在血管供應豐富的椎體上，有報告指出，正常年齡老化會使椎體血液灌流下降，或者骨質疏鬆症與椎體黃骨髓比例上升，也都會使椎體血液灌流下降。使用雙分室藥物動力學模型分析DCE-MRI椎體血液灌流，可以達到定量分析，此模型會產生四個獨立微灌流參數K^(trans)、K_(ep)、v_e、v_p，要使用此模型進行定量分析，動脈輸入函數（Arterial input function, AIF）是必要的條件，對椎體DCE-MRI可以使用主動脈或是椎動脈的AIF，但兩種不同的AIF會得到不同的微灌流參數。本篇目的是比較主動脈AIF與椎動脈AIF分別帶入DCE-MRI模型進行運算，觀察在骨質疏鬆症患者的腰椎微灌流定量分析的影響。然而在骨質疏鬆的人K^(trans)與v_e會有顯著不同於骨質密度正常的人，不論使用主動脈AIF或椎動脈AIF都可以區別正常椎體與骨質疏鬆椎體的微灌流差異。

關鍵字

動態對比增強磁振造影 ； 動脈輸入函數 ； 椎動脈 ； 骨質疏鬆

並列摘要

Dynamic contrast-enhanced MRI (DCE-MRI) is a noninvasive technique widely used to evaluate the blood perfusion of the vertebra. Osteoporosis is a bone disease that causes a loss of bone mass. Studies in recent decades have shown the relationship between peripheral vascular disease and the loss of bone mass. Two compartment model based on dynamic contrast-enhanced MRI (DCE-MRI) is a quantitative analysis by four parameters (K^(trans), K_(ep), v_e, and v_p ) for exploring vertebra perfusion. The arterial input function (AIF) is a necessary factor for two-compartment model, aorta AIF (AO_AIF) and the segmental artery AIF (SA_AIF) are commonly used. However, the different AIF will influence the perfusion results. In this study, vertebra perfusion in subjects with osteoporosis and normal BMD was used to evaluate the variation between AO_AIF and SA_AIF in clinical applications. Our results have demonstrated that the absolute values of perfusion parameters were different in AO_AIF and SA_AIF. However, the significant differences in K^(trans) and v_e between osteoporosis and normal groups are not affected by AO_AIF or SA_AIF.

並列關鍵字

DCE-MRI ； AIF ； Segmental artery ； Osteoporosis