This study numerically investigates the mixed flow pump performance with the commercial design software, CFturbo, and the computation fluid dynamics software, ANSYSCFX. The mixed flow pump is made up of three impellers: the casing, the bowl diffusers and the guide vanes. The CFturbo software package is utilized to design the primary geometry of the impeller inlet and outlet, the impeller diameter, the blade thickness, the number of blades, the diffuser, and guide vane. The ANSYS-CFX is applied to analyze the flow field among the impeller, the bowl diffuser, and the guide vanes. The parameters in this article include different flow rate to find mixed flow pump working zone. The numerical results also show that the mixed flow pump flow field phenomenon at different operation conditions and the performance improvement effect.