生物可降解鎂合金止血夾製程研究

Development of Biodegradable Hemostatic Clips Made by Magnesium Alloys

邵順裕 ； 許傳仁 ； 曾俊傑 ； 洪忠佑

《機械工業雜誌》 429期 (2018/12) Pp. 48-55

摘要

鎂合金具有優秀綜合力學性能、良好生物相容性及生物可降解吸收性等特點，為理想手術材料，能增加術後追蹤之可行性與確定性。然目前鎂合金相關醫療器械只有極少數核准上市，其原因在於目前仍有許多問題亟待解決，包括：成形技術難度高、降解速率難調控及可降解金屬生物相容性評價等，均阻礙鎂合金醫材發展。本研究為開發可降解鎂合金止血夾，從合金成份設計，透過微量元素添加以控制材料可成形性及降解速率；後經熔鑄成料錠後以擠壓成形製造條棒材，再經伸線製程製造成線材後，由製釘機製成止血夾樣式，未來將提供微創止血手術使用。

關鍵字

生物可降解 ； 鎂合金 ； 止血夾

並列摘要

Magnesium alloys have excellent mechanical properties such as good biocompatibility and biodegradable absorbability. Magnesium alloys are ideal surgical materials because they may facilitate postoperative follow-up. However, few medical devices made by Magnesium alloys are clinical approved in market. There are still many challenges need to be addressed for Magnesium alloy based medical devices, such as the control of degradation rate, limited formability and inherent biocompatibility. This study is to develop a hemostatic clip made by biodegradable magnesium alloy. Selected elements are added to Magnesium based alloy in order to control the formability and degradation rate. Processes to make the hemostatic clip with proposed alloy are introduced. The developed hemostatic clip is expected to be used for surgery in the future.

並列關鍵字

Biodegradable ； Magnesium alloy ； Hemostatic clip