The Commentary on the Diamond Sutra is one of the most important sutra commentaries by Venerable Master Hsing Yun. This commentary is significant in comprehending Venerable Master's concept of Humanistic Buddhism, and in understanding the method and concept of modern day interpretation of sutras on Humanistic Buddhism. This paper gives a preliminary study on the basic concept of this commentary by Venerable Master. The research focuses on two aspects: "the spirit of Humanistic Buddhism denoted in Venerable Master Hsing Yun's interpretation of the Diamond Sutra" and "the concept of skillful means and its applications characterized in Venerable Master Hsing Yun's interpretation of the Diamond Sutra." This commentary by Venerable Master embodies the concept of interpretation, which provides an important guidance in understanding the method and concept of interpreting scriptures on Humanistic Buddhism in modern times.