The purpose of this study was to explore the learning effects of "Direct Instruction on literacy" to students with disabilities from elementary special class。The research method uses the A-B-A' withdrawal experimental design in a single subject design. The study was attended by three children with disabilities who were enrolled in a elementary school from special class in Miaoli County. After the "Direct Instruction" teaching, there were immediate and maintenance effects on literacy of phonics, literacy of words, literacy of vocabulary, and literacy of sentences to students with disabilities from elementary special class.