Fe, one of the most abundant and well studied non-traditional stable isotopes in the earth's crust, has a specific atomic number (26), atomic weight (55.845) and density (7.86g/cm^3). At present, it is found that there are three valence states of Fe in minerals, rocks and fluids that have undergone various geochemical processes: metallic iron (Fe^0), bivalent iron (Fe^(2+)) and trivalent iron (Fe^(3+)).The four stable isotopes were ^(58)Fe (0.33%), ^(57)Fe (2.25%), ^(56)Fe (91.52%) and ^(54)Fe (5.90%).In recent years, as for the cause of Fe isotope composition, migration, sorting, distribution, research development, and testing methods, the improvement of experimental equipment and complete, and gradually develop and use Fe isotopes, fluid out of the soluble and evolution process of magma, metallogenic material source and genesis, biological absorption and induction process, the fractionation mechanism, the mantle metasomatism, etc were studied. With the further development, the application of Fe isotopes will be an extremely important analytical means in the multidisciplinary research progress of geochemistry and even cosmology in the future.