Under the background of building "double first-class" University in China, how to cultivate talents who adapt to social development, serve the society, have strong practical ability, innovative spirit and initiative innovation ability are the important issues facing colleges and universities, especially local colleges. Biotechnology and biopharmaceutical specialty have the characteristics of application and practice. The system of scientific research tutor for undergraduates is the reform mode of practical teaching which meets the needs of innovation ability cultivation. This paper, based on the development status of undergraduate scientific research tutor system, which has been implemented for eight years in biotechnology and biopharmaceutical specialty of Weifang Medical College, expounds that it is imperative to improve the thinking, self-study and innovation ability of Undergraduates in scientific research and cultivate innovative talents with high-level application.