Objective: To explore the application effect of targeted monitoring and intervention in the prevention of urinary tract infections in patients with indwelling urinary catheters in urology. Methods: From April 2020 to May 2021, 120 patients who needed indwelling catheters in the Department of Urology in our hospital were selected and randomly divided into control group and observation group by random number table, with 60 cases in each group. Among them, the control group adopts conventional nursing measures, and the observation group conducts targeted monitoring and intervention on patients with indwelling catheters on the basis of conventional nursing. The nursing effects of the two groups were compared. Results: The indwelling time of the urinary catheter and the recovery time of spontaneous urination in the observation group were significantly shorter than those in the control group. And the incidence of catheter-related urinary tract infection was significantly lower than that of the control group (P<0.05). The satisfaction of patients in the observation group with nursing work was significantly higher than that in the control group (P<0.05). Conclusion: Targeted monitoring is an important monitoring method and guiding standard for controlling urinary tract infections in patients with indwelling catheters. In response to the results of targeted surveillance, targeted intervention measures are of positive significance for the prevention and treatment of infection.