The problem of uneven regional economic development is widespread in China, as is the economic development of cities within Sichuan Province. This paper selects 12 macroeconomic indicators from four aspects: economic development, education and human resources, transportation and medical security, and comprehensively analyzes the economic development of 21 prefecture‐level cities in Sichuan Province in 2019. Firstly,the factor analysis method was used to reduce the dimensionality of 12 variables, and the scores and comprehensive scores of each factor were calculated. Secondly, cluster analysis is carried out based on the comprehensive scores of factors of various cities at the local level, so as to have a full understanding of the economic development of various regions in Sichuan Province.