【論文摘要】The Effect of Beta-blockers on Major Adverse Cardiac Events for Both Primary and Secondary Prevention: A Long-term Follow-up Result of T-SPARCLE and T-PPARCLE Registry in Taiwan

Patrick Yan-Tyng Liu ； Chau-Chung Wu

《海峽循環醫學雜誌》 1卷2S期 (2019/09) Pp. 119-121

https://doi.org/10.6907/SCJ.201909/SP_1(2).0096

摘要

Background/Synopsis: The benefit of long-term use of beta-blockers for primary and secondary prevention on major adverse cardiac events (MACEs) is challenged in present coronary reperfusion era. Objectives/Purpose: To clarify the effect on MACEs by using two multi-center observational registries in Taiwan. Methods/Results: Patients with known atherosclerosis cardiovascular disease (ASCVD) were included in Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (T-SPARCLE) registry, and patients with at least one risk factor of ASCVD were included in Taiwanese Primary Prevention for patients with AtheRosCLErotic disease (T-PPARCLE) registry. The primary outcome is the time of first occurrence of a MACE. Enrollment included 11,747 eligible patients (6,921 and 4,826 in T-SPARCLE and T-PPARCLE, respectively) between December 2009 and November 2014 with a median 2.4 years follow-up. Among them, 273 patients (2.3%) met the primary endpoint. Beta-blocker use was 42.9% of patient with MACE, as compared with 52.4% of those without MACE (P ＜ 0.01). In patient with ASCVD, beta-blocker use was associated with lower events of MACEs (hazard ratio, 0.72; 95% CI, 0.55 to 0.94; P ＜ 0.001). The benefit of beta-blocker use was not significant in those without ASCVD (P = 0.88). Conclusion: In ASCVD patients, beta-blockers use was associated with a lower rate of MACEs occurrence, and the effect was remained in long-term follow-up. The benefit of beta-blocker was not significant in non-ASCVD patients.