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【論文摘要】Detection of High Ratio of Soluble to Membrane-bound Lectin-like Oxidized Low-density Lipoprotein Receptor-1 in Aspirated Coronary Thrombi in Patients with ST-elevation Myocardial Infarction
摘要
Background/Synopsis: Circulating levels of soluble lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (sLOX-1), released after proteolytic cleavage of membrane-bound LOX-1, have been proposed as a useful biomarker of acute myocardial infarction (AMI). L5, the most electronegative LDL, can signal through LOX-1 to trigger atherogenesis. Objectives/Purpose: We sought to examine the characteristics of LOX-1 in the aspirated thrombi and explore the role of L5 in AMI patients. Methods/Results: Intracoronary thrombi were aspirated by interventional thrombosuction for immunohistochemical analyses from patients with ST-elevation MI (STEMI; n=32) and non-STEMI (NSTEMI; n=10). LOX-1 was robustly expressed with a higher ratio of sLOX-1 to membrane-bound LOX-1 in STEMI than in NSTEMI thrombi. In aspirated thrombi, LOX-1 was co-localized with apoB100, a main lipoprotein component of LDL. To explore the role of L5, we found that L5 but not L1 (the least electronegative LDL) particles quickly formed aggregates prone to be retained in thrombi using deconvolution microscopy. In vitro study of L5- or L1-treated monocyte cell line showed that L5 induced cellular adhesion and provoked differentiation of monocytes to macrophages in a dose dependent manner. In a separate AMI cohort, the plasma level of sLOX-1 was higher and positively correlated with the plasma level of L5 in STEMI patients (n=33) than in NSTEMI patients (n=25). Conclusion: LOX-1 was more abundant with a higher ratio of sLOX-1 to membrane-bound LOX-1 in aspirated thrombi and a greater circulating level of sLOX-1 in STEMI patients than in NSTEMI patients. L5 might play a role in the release of high-level of sLOX-1 into circulation in STEMI patients.
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