【論文摘要】Association between Alcohol Consumption and Metabolic Syndrome According to Facial Flushing in Korean Females

Yuri Seo ； Jongsung Kim

《海峽循環醫學雜誌》 1卷2S期 (2019/09) Pp. 47-47

https://doi.org/10.6907/SCJ.201909/SP_1(2).0040

摘要

Background/Synopsis: Some of the Asians, including Koreans, have genetic variations of nonactive aldehyde dehydrogenase 2 (ALDH2), which is related to alcohol metabolism, leading to higher percentage of facial flushing in Asians. Differences in metabolic ability of aldehyde result in differences to individual alcohol metabolism abilities during alcohol consumption. Women have higher levels of blood alcohol concentration compared to men despite the same levels of alcohol intake. This is because women have higher body fat, lower ratios of water and have lower ADH activity within the stomach, which ultimately ties into lower alcohol metabolism. Objectives/Purpose: This study aimed to examine the relationships between alcohol consumption and metabolic syndrome according to facial flushing caused by drinking in Korean females. Methods/Results: Among the female patients aged ＜65 who visited the health promotion center at a single university hospital from January 2016 to March 2017, 1344 women were included. After adjusting for confounding factors such as age, body mass index, smoking, exercise or menopausal status, a multiple logistic regression analysis was performed to assess the association between alcohol consumption and the risk of metabolic syndrome in the facial flushing and nonfacial flushing groups compared with the nondrinkers. Even after adjusting for confounding factors, the risk of metabolic syndrome was significantly increased in all drinking subgroups (≤2 standard drinks (OR, 1.68; 95% CI, 1.10 to 2.68), 2＜,≤4 standard drinks (OR, 2.48; 95% CI, 1.29 to 4.74), ＞4 standard drinks (OR, 4.16; 95% CI, 2.03 to8.30)) in the facial flushing group. The risk of metabolic syndrome was significantly increased only in the subgroup with a weekly alcohol consumption ＞4 standard drinks (OR, 2.20; 95% CI, 1.07 to 4.52) in the nonfacial flushing group. Conclusion: This study suggests that Korean women with flushing when drinking show a higher risk of metabolic syndrome at lower weekly drinking amount than those without flushing.