【論文摘要】Association between Serum Uric Acid Level and Subclinical Coronary Atherosclerosis in Asymptomatic Individuals

Gyung-Min Park ； Doo-Ho Lim

《海峽循環醫學雜誌》 1卷2S期 (2019/09) Pp. 61-61

https://doi.org/10.6907/SCJ.201909/SP_1(2).0051

摘要

Background/Synopsis: High serum uric acid (SUA) is the main prerequisite for gout, and might be associated with obesity, hypertension, glucose intolerance, insulin resistance and dyslipidemia which is known as risk factors for coronary artery disease. The association of SUA level with coronary artery disease has been investigated, but results are conflicting. Furthermore, there are limited data on the association between SUA level and subclinical coronary atherosclerosis. Objectives/Purpose: We sought to investigate the influence of SUA on subclinical coronary atherosclerosis as detected by coronary computed tomography angiography (CCTA) in an asymptomatic population. Methods/Results: We evaluated a total of 6,431 asymptomatic individuals with no prior history of coronary artery disease who voluntarily underwent laboratory test and CCTA as part of a general health examination (mean age 53.6 ± 7.6 years and 4,691 men [72.9%]). Study participants were stratified into quartiles according to their SUA levels. Coronary atherosclerotic plaques (calcified, mixed, and non-calcified plaque) by CCTA were assessed. Logistic regression analysis was used to determine the association between SUA and subclinical coronary atherosclerosis. The prevalence of any atherosclerotic, calcified, mixed, and non-calcified plaque increased with SUA quartiles (p for all＜0.001). After adjustment for cardiovascular risk factors, there were no statistically significant differences in the adjusted odds ratios for calcified plaque (1.18; 95% confidence interval [CI] 0.97-1.45; p=0.097) and mixed plaque (1.24; 95% CI 0.93-1.66; p=0.141) in the fourth SUA quartile compared to the first quartile. However, the adjusted odds ratios for any atherosclerotic plaque (1.40; 95% CI 1.16-1.68; p＜0.001) and non-calcified plaque (1.39; 95% CI 1.12-1.73; p=0.003) were significantly higher in fourth SUA quartile. Conclusion: In asymptomatic individuals, high SUA level was an independent predictor for non-calcified plaque, suggesting an increased cardiovascular risk.