【論文摘要】Association of Pulsatility and Resistive Indices at Four Sites of Superficial Arteries with Severity of Atherosclerosis in Patients with Essential Hypertension

Min-Yi Lee

《海峽循環醫學雜誌》 1卷2S期 (2019/09) Pp. 75-75

https://doi.org/10.6907/SCJ.201909/SP_1(2).0063

摘要

Background/Synopsis: Carotid atherosclerosis is a relevant predictor of future cardiovascular events. Two derived indices from flow velocities - resistive index (RI) and pulsatility index (PI) - were initially regarded as markers for atherosclerotic alterations in renal arteries. Objectives/Purpose: In the present study, we measured RI and PI in four site superficial arteries, including carotid, brachial, radial and femoral arteries in patients with essential hypertension, to determine the most relevant vessel to which allowed us for quantitative evaluation of peripheral atherosclerosis. Methods/Results: Methods: Carotid intima-media thickness (IMT) and plaque burden were evaluated in bilateral carotid arteries using duplex ultrasound in 79 hypertensive patients. The severity of plaque burden was manifested with plaque score. Meanwhile, RI and PI of four superficial arteries were calculated in all subjects. Univariate and multivariate logistic regression analyses were used to relate the hemodynamic parameters with carotid IMT and plaque burden. Results: Carotid plaque score had significant associations with carotid PI (p = 0.009) and RI (p = 0.002), brachial PI (p = 0.048) and RI (p = 0.007), and femoral RI (p ＜ 0.001). Carotid IMT had significant associations with carotid PI (p = 0.033) and femoral RI (p = 0.047). Multivariate logistic regression analysis associated with increased carotid plaque score was femoral RI (odd ratio = 6.770, p = 0.009) after adjusting for confounding factors including age, serum creatinine, total cholesterol and low density lipoprotein cholesterol. Conclusion: Conclusion: Femoral RI is significantly associated with carotid plaque burden and IMT. Hence, femoral RI could be a good alternative indicator for assessment of atherosclerosis.