急性缺血性腦中風之幹細胞相關治療

Stem cell-related therapy has become one of the most important research topics in stroke treatment. This novel therapy can be classified into three strategies: exogenous stem cell transplantation, treatment with extracellular vesicles (EVs) and secretome from stem cells, and enhancement of endogenous neurogenesis. Intravenous, intra-arterial, or intracerebral transplantation with various sources of stem cells improved functional outcome in animal models of acute ischemic stroke. The therapeutic mechanisms include anti-inflammation, anti-apoptosis, enhancement of neurogenesis/angiogenesis and neuroplasticity. Recent clinical trials focusing on intravenous autologous/allogenic transplantation of mesenchymal stem cells or multipotent adult progenitor cells demonstrated good safety and potential beneficial results and numerous clinical trials are ongoing. In addition, direct intravenous treatment with stem cell-related EVs (exosome and microvesicles) or secretome also benefited stroke models. Induction of post-stroke endogenous neurogenesis using growth factors or small molecules is another cell-free alternative strategy of cell therapy for acute ischemic stroke. With advanced pre-clinical and clinical results available, stem cell-related therapy might be a standard treatment for ischemic stroke in the near future.

並列關鍵字

Cell therapy ； Ischemic stroke ； Stem cell ； Stem cell therapy

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急性缺血性腦中風之幹細胞相關治療

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