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摘要


觀察型研究發現,血中總膽固醇與或低密度脂蛋白膽固醇(low density lipoprotein cholesterol[LDL-C])的濃度升高,和腦中風的風險增加有相關性,特別是與大動脈粥狀硬化相關的缺血性腦中風。如果有血脂異常,無論是否使用藥物治療都應進行生活型態改善。對於動脈粥狀硬化相關或非動脈粥狀硬化相關但合併有冠狀動脈疾病的的缺血性腦中風或短暫性腦缺血(transient ischemic attack[TIA])的病人,應使用高強效或中強效statin治療以預防未來發生的主要心血管事件,必要時可合併ezetimibe,來降低LDL-C <70 mg/dL,且急性期過後持續使用statin是合理的。急性缺血性腦中風或TIA病人,如LDL-C >100 mg/dL或中風前有使用statin,於急性期住院期間使用statin是合理的。對於症狀性頸動脈狹窄或顱內動脈狹窄病人,控制LDL-C <70 mg/dL是合理的。對於無症狀頸動脈狹窄或顱內動脈狹窄病人,控制LDL-C <100 mg/dL是合理的。

並列摘要


Observational studies show that elevated total cholesterol or low density lipoprotein cholesterol (LDL-C) is associated with an increased risk of stroke, especially in stroke related to large artery atherosclerosis. If dyslipidemia is found, life style modification is needed regardless of medical therapy. It is reasonable to use high-intensity or moderate-intensity statin, with ezetimibe if necessary, to lower LDL-C below 70 mg/dL to prevent risks of future cardiovascular events in patients with atherosclerotic ischemic stroke or with non-atherosclerotic ischemic stroke but having coronary artery disease, and use statin continuously after acute stage. It is reasonable to use statin in acute ischemic stroke patients during hospitalization if their LDL-C >100 mg/dL or they already taking statin before index stroke. It is reasonable to control LDL-C <70 mg/dL in symptomatic carotid or intracranial artery stenosis while control LDL-C <100 mg/dL in asymptomatic carotid or intracranial artery stenosis.

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