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In 2020, the Taiwan Stroke Society (TSS) published the guideline on antiplatelet therapy for noncardioembolic ischemic stroke. The content of the guideline covered three major topics for the timing and optimal antiplatelet treatment strategy in secondary prevention, acute management, and primary prevention for noncardioembolic ischemic stroke. Nevertheless, new trials related to the use of dual antiplatelet therapy (DAPT) in patients with minor stroke or high risk transient ischemic stroke (TIA) have been published and the analytic results may substantially change the clinical practice. Therefore, an update focusing on the dual antiplatelet therapy in this specific population is necessary. This focused update of the 2020 guideline was made based on the scientific evidence and endorsed by the TSS Guideline Consensus Group. It addressed three major topics including the timing of initiating DAPT after stroke or TIA, combing ticagrelor and aspirin in patients with mild to moderate ischemic stroke or high-risk TIA and treatment strategy in patients carrying CYP2C19 loss of function allele. The reviews of the literatures and recommendations are provided in the manuscript.

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