- 期刊
- OpenAccess
Preliminary studies on therapeutic effect of ethanolic extract of Tylophora villosa leaves against paracetamol-induced hepatotoxicity in mice
摘要
This study intended to investigate the therapeutic effect of ethanolic extract of Tylophora villosa leaves (E2TL) against paracetamol (PC)-induced hepatotoxicity (PCIH) in mice (Mus musculus). PCIH were generated using daily 250 mg/kg body weight (bw) PC administration by gavage for seven days, and then daily 27.5; 55.0; 82.5; 110.0; or 220.0 mg/kg bw E2TL were treated by gavage for seven or fourteen days. Meanwhile, the controls were given solvent only in the same manner. Mortality, blood glucose, and condition (color, weight, volume) of the livers were observed on day 15 (D15). Serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SG0T) were examined on D15, D22, and D30, and then malondialdehyde (MDA) was determined on D15. Results of this study revealed that on D15, the dosage of 110.0 mg/kg bw E2TL most effectively decreased MDA due to PCIH, from 6.78 ± 1.70 μmol/L to 3.45 ± 0.43 μmol/L, approaching the control condition (2.45 ± 0.05 μmol/L). PC administration was really toxic dosage and caused 13.3 % mortality. Blood glucose, weight, and volume of the liver decreased as the effect of PC administration, and then 220.0 mg/kg bw E2TL treatment could recover the condition as well as the controls. Color of the liver indicated a similar recovery by E2TL treatment. SGPT and SG0T increased significantly by PC administration, and this PCIH facts could be recovered gradually near the controls according to the dosages (55.0; 110.0; or 220.0 mg/kg bw) and duration (seven or fourteen days) of E2TL treatment. It could be concluded that E2TL showed therapeutic effect against PCIH in M. musculus.
參考文獻
延伸閱讀
- Buraimoh, A. A., Bako, I. G., & Ibrahim, F. B. (2011). Hepatoprotective Effect of Ethanolic Leave Extract of Moringa oleifera on the Histology of Paracetamol Induced Liver Damage in Wistar Rats. International Journal of Animal and Veterinary Advances, 3(1), 10-13. https://www.airitilibrary.com/Article/Detail?DocID=20412908-201102-201509210020-201509210020-10-13
- Doosti, M. H., Ahmadi, K., & Ramandi, M. F. (2018). The effect of ethanolic extract of Thymus kotschyanus on cancer cell growth in vitro and depression-like behavior in the mouse. Journal of Traditional and Complementary Medicine, 8(1), 89-94. https://doi.org/10.1016/j.jtcme.2017.03.003
- Olayode, O. A., Daniyan, M. O., & Olayiwola, G. (2020). Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats. Journal of Traditional and Complementary Medicine, 10(6), 544-554. https://doi.org/10.1016/j.jtcme.2019.05.001
- 江詩雯（2004）。Effects of phytopolysaccharide extract on cell proliferation in hepatocellular carcinoma and T lymphoma cells〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714553831
- Spencer, C. N., Sunday, J. J., Usunomena, U., Udoka, N., Akintola, A. A., Ehiremen, O. I., & Kingsley, O. (2011). Effects of Aqueous and Ethanolic Extract of ＂Vernonia amygdalina＂ Leaf on the Plasma Lipid Profile and Liver Function Parameters of Normal Rats. Current Research Journal of Biological Sciences, 3(5), 504-508. https://www.airitilibrary.com/Article/Detail?DocID=20410778-201109-201512280013-201512280013-504-508