After research the influencing factors of the persistent dissemination of Internet buzzwords and determine the deep mechanism of Internet buzzwords becoming strong memes, we can use some key conditions to achieve the corresponding dissemination needs, or limit and weaken certain conditions in the corresponding steps to reduce the popularity or durability of the dissemination and provide a useful reference for the spread and management practices of Internet buzzwords. By collecting data of typical and representative buzzwords from 2011 to 2018, we use the crisp set qualitative comparative analysis method to explore the key influence factors of buzzwords' channels, events and structural characteristics on their lasting spread. The research found that there are 8 effective paths for persistent dissemination, which can be summarized into five modes: public figure channels, ordinary people channels, authoritative forwarding channels, appealed genotypes buzzwords, and exogenous buzzwords.