The reliability of modular multilevel converter (MMC) is the premise to ensure the stable operation of the whole system. Therefore, when the fault occurs on the sub-module (SM), it is necessary to detect and locate it quickly and accurately to avoid the shutdown of the whole system. Based on the analysis of the open-circuit fault characteristics of the SM, a fault detection strategy of MMC power switch based on logic operation is proposed in this paper. The algorithm detects and locates the open-circuit fault according to the inconsistency between the binary output signal of the SM terminal voltage and the trigger signal of SM upper switch. Finally, the MMC simulation system is built in MATLAB/Simulink, and the results show that the proposed strategy can effectively reduce the calculation amount of fault diagnosis. It also can detect and locate IGBT open-circuit fault quickly and accurately. This method is simple to implement and does not need additional voltage measuring equipment.