Chronic kidney Disease is a frequently occurring and common disease in clinic. However, due to the complexity of pathogenesis and clinical symptoms and the endless emergence of complications, people are helpless. It not only consumes huge medical resources, but also has many negative effects on people's production and life. Therefore, it is of great significance for the early prevention and treatment of the disease. Three causes theory" is an important part of the basic theory of traditional Chinese medicine, and it is also the concentrated embodiment of the overall concept of traditional Chinese medicine and the thought of syndrome differentiation and treatment. "Three causes theory", that is, adjusting measures to time, local conditions and individual conditions, is one of the basic treatment principles of traditional Chinese medicine, and fundamentally follows the principle of dialectical treatment of traditional Chinese medicine. This paper will elaborate the application of early prevention of chronic kidney disease according to individual conditions, local conditions and time conditions, hoping to guide clinical diagnosis and treatment and provide some treatment ideas for the prevention and treatment of traditional Chinese medicine.