With the rapid development of social economy and the arrival of the information age, the scale of enterprises is becoming larger and larger. There is more and more information about warehouse management, staff management, parts procurement, supplier selection and product selection. The establishment of enterprise management information system is a very important step in the development of information technology. After accurately understanding the user requirements of the enterprise information management system, this paper gives a detailed database system design process. The system has the functions of enterprise employee management, supplier management and warehouse product management. Finally, the enterprise management system based on Web platform is developed. The experiment shows that the system has good practicability.