Aiming at the problem of emergency supplies distribution in the 5G network environment, this paper solved the optimization scheme of vehicle UAV cooperative distribution through the cooperative operation of vehicles and drones, aiming at solving the problem of emergency supplies distribution in emergencies. The greedy algorithm was used to split the overall distribution optimization problem into single collaborative distribution optimization, and the K-means clustering algorithm was used to divide the single path optimization subgraph. For single path optimization, the optimal goal is to minimize the single path planning distance in the optimization subgraph, and the hybrid integer programming model is solved by genetic algorithm. The application of the model can provide a better solution for the distribution of emergency supplies.