In view of the current eye tracking technology has a direct, can replace traditional human-computer interaction operation sensitivity and natural features, this article to control science, cognitive science, computer science, behavioral science theory as the instruction, constructs the eye movement data model and eye movement behavior model, designed the eye movement interaction mechanism and real-time recognition algorithm of eye movement behavior, Virtual keyboard eye control system and unmanned platform eye control system are realized. Firstly, in order to reflect the temporal and spatial characteristics and variation trend of eye movement information, a spatio-temporal cube model based on eye movement data was constructed. Then, region-based eye-movement interaction mechanism was designed, and three eye-movement behavior models of fixation, eye potential and conscious blinking were constructed based on this, and real-time recognition algorithms were designed respectively for these three kinds of eye-movement behavior. Then, according to the principle of eye movement interaction, a human-computer interaction system design framework based on eye movement is proposed, and the interaction instructions are formally represented.