In the early 21st century, with China's accession to the world trade organization, there are more and more business exchanges and cooperation with other countries. Business English translation has become an important driving force to promote the rapid development of China's international trade. However, due to the obvious cultural differences between the East and the west, there will be some difficulties in Business English translation. Therefore, the study of business English translation from a cross-cultural perspective is of great significance to the development of business trade in China. This paper makes a series of studies on the characteristics of business English translation, the influence of cultural differences on business English translation and the strategies to solve the problems.