In order to study the changes of savings deposits of urban and rural residents in Anhui Province under the new economic normal development since the reform and opening-up in the 21st century and the influence degree of different factors, this paper puts forward some reasonable suggestions for future economic development. In this paper, the relevant data of urban and rural residents' deposits in Anhui province from 1999 to 2019 are selected, the balance of urban and rural residents' deposits in Anhui province is taken as the explanatory variable, and the per capita disposable income of urban and rural residents, one‐year nominal deposit interest rate and consumer price level in Anhui province are taken as explanatory variables, The model is established by using Eviews9.0 software, and the factors affecting urban and rural residents' deposits in Anhui province are analyzed, tested and revised, and some suggestions are given.