To study convenient traffic conditions and infrastructure facilities construction how to prompt the coordinated development of regional economy, this article takes the opening of Chengdu-Chongqing high-speed rail as the research object, and uses panel data of 211 counties (districts) in Chengdu-Chongqing region from 2014 to 2018 to empirically test the relationship between the opening of high-speed rail and regional economic development . The results show that the opening of the Chengdu-Chongqing high-speed rail can promote the improvement of regional economic development. The spillover effect of the opening of high- speed rail on regional development is more prominent in small and medium-sized counties and districts. After the opening of high-speed rail, the increase in investment in counties and districts has a certain inhibitory effect on the overall economic development of the region . To this end, this article provides a policy reference for promoting the construction of the dual-city economic circle in the Chengdu-Chongqing region in terms of accelerating regional integration construction planning, coordinating urban and rural development, and accelerating the flow of resources across regions.