In recent years,our country has paid more and more attention to the coordinated development and win-win of manufacturing and environment, which has led a large number of scholars to study environmental regulation and the upgrading of manufacturing industry. Based on the literature research results at home and abroad, this paper sorts out and evaluates the connotation, evaluation index and correlation between environmental regulation and manufacturing upgrading. The purpose is to better understand the relationship between environmental regulation and manufacturing upgrading, and explore the influence of environmental regulation on manufacturing upgrading, so as to further enrich the research foundation of regional manufacturing upgrading under the background of environmental regulation.