Based on how to achieve high-efficiency allocation of medical resources in various regions and accurately prevent and control the epidemic situation in the post-epidemic era, this paper uses data envelopment analysis (DEA) to establish an evaluation model to compare the utilization of medical resources in Jilin, Shanghai and Wuhan in 2019 and 2020, and analyzes the epidemic prevention and control effects of these three regions, finding out the shortcomings and defects in medical resource allocation and epidemic prevention and control, and making suggestions for achieving high-efficiency allocation of medical resources, accurately preventing and controlling the epidemic situation and ensuring people's life safety in the post-epidemic era.